Oh I am very much a terrible fighter but Skull Cavern can still be fun for the general looting of Treasure Rooms and random drops. How I make Skull Cavern fun, a short guide for terrible fighters:
High Luck day
Lucky Lunch or
Magic Rock Candy for more Luck and evasive Speed
Staircases for "they who
fights and runs away, lives to
fight another day also run away on the next Skull Cavern Level." Famous SDV quote, probably
Bombs for
BOOM, also grabbing lotsa shiny things
Galaxy Sword or better to swing about wildly for those who forget the crossed out bits above. Bonus: the wind your uncontrolled flailing creates may occasionally blow a monster farther away
Gold Star Cheez for healing (or your fave food)
Iridium Pickaxe for the few things you'll need to pick
You can always use earlier game or lower quality options like a lower Luck day, Spicy Eel and Coffee, Cherry Bombs, Lava Katana (maybe Dark Sword or Obsidian Edge), Blue- Cran Blackberries or Salad, or Gold Pickaxe, but only as long as you have enough extra Stairs to spam down to save your tasty kneecaps.
My 2 best suggestions are:
• Always have Stairs ready and just slap 'em down and escape if you're even vaguely questioning how infested a floor is
• Always have Food ready to eat, eat at no less than 3/4 health if you're using Salad or Berries, or 1/2 health with anything better like Cheez.
Food is cheap. Your life is not.