Giant Octopodes
Farmer
Dragontooth Club is certainly a great option for a hybrid approach, and I'm not knocking it at all - but I will say that the word "best" is I think too strong for, well any weapon, given that it's all tradeoffs.
If you're going Scout - Desperado with a Dragontooth Club with 3 Aquamarines, as compared to Scout - Acrobat with say the Infinity Gavel with 3 Rubies, you're dealing way less damage (minimum damage 80 vs 130, so about 60% of the damage), and you have twice as long of a cooldown between special attacks. So it's much more likely you fail to OHKO an enemy (especially those on the edge), and far more punishing if you do. Meanwhile compared to the Dragontooth Cutlass with the same setup of Scout - Desperado and 3 Aquamarines, you're attacking every .4 seconds instead of every .72, or about twice as often. That means it's not nearly as punishing to stop and take 1 swipe at an enemy if you crit, and for every time you need to swing again fishing for that crit, the discrepancy gets worse.
So as with most hybrid setups, you're better than either of the alternatives in the areas they're weak in exchange for being much worse in the areas they excel. Now none of this includes the effect of inherents, I need to test extensively once I get to that point of the game again with them and trinkets and so forth. And I don't doubt that for many people in many circumstances the dragontooth club ends up being the most effective overall. But "best" is nonetheless a bridge too far in my book.