Hard agree on the ghosts. I'm in a hurry here, I ain't have no time waiting for you to carry your ectoplasmic corpse closer at 1 cm/h
Apart from that, the spiders in the dangerous mines. These things make the middle section such a miserable slog, levels 80 to 120 are a leisurely stroll in the park in comparison. Also the squids in the upper levels are annoying as well, but not to the extent of the spiders, or maybe it's the levels themselves that are balanced better, I don't remember, been a while since I've gone through the dangerous mines.
Also also, I always seem to struggle way more than necessary against the mini purple slimes in Skull Cavern, but the way they swarm around you makes it harder to stick them against a wall. And they have soooo much health points and not so much knockback. Long live the Slime Charmer ring so I can just ignore them
