It really depends on device and level of impairment (and more of course). I'd say it might be a struggle on small phone screens, especially if you want to zoom out and see everything instead of playing very zoomed in. If you are playing on a tablet it's absolutely playable, with the screen of that decent size at a close distance it should be quite legible.
One thing that may be hard would be item descriptions/letters/written notes, I'd recommend mods, there are screen reader mods and I believe ones that can impact font size too which I would find a big help even without any vision impairment.
Good luck with whatever you try, please share your experiences if it does work for you