I used to suck at Skull Cavern runs like we all probably did at first. I was terrible at it for years, but here's what helped me have fun in Skull Cavern.
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Loadout
• Staircases are #1 because you can instantly toss one down and escape (duplicate Jade in Crystalariums and trade for Stairs at Desert Trader on Sunday), take
200!
•
Cheese is #2 as it heals half your health in one go and is very easy to make (happy Cow + Cheese maker makes one per day), take
40+!
• High damage Sword is #3:
Galaxy (first Prizzy Shard),
Lava Katana ($25k @Guild),
Obsidian Edge (Mines Floor 90) in order of best&rare to good&guaranteed
• Gold or
Iridium Pickaxe is #4 as you need pickaxe speed here
If I had these 4 things alone, could I do a fun Skull Cavern run? I think so and I will test this on my next
High Luck day. I recommend High Luck days for increased Treasure Rooms, Gem nodes, and Ladder spawns. All these things are fun!
But there are
other items that really make the little things in Skull Cavern easier (for me!):
• Bombs: this is all about speed, ignore your Pickaxe and just clear a collection of tasty gem and Iridium nodes in one go, take
100! (Duplicate Quartz in Crystalariums and Desert Trader 5 for 1 Bomb)
• Slime Charmer Ring:
completely ignore Slimes, this makes your run
soooo much more relaxed
• Iridium Ring for Light + Magnet + 10% damage
• Luck Buff (
Lucky Lunch, Spicy Eel, Ginger Ale), take
~3 as they wear off
• Speed Buff (
Spicy Eel, Coffee, TS Espresso), take
~3 as they wear off (or
10 Coffee)
** Spicy Eel is
also available from the Desert Trader, duplicate Rubies in Crystalariums and trade!
I use the 2 Buffs in these combos:
Mid game:
Spicy Eel + Ginger Ale for +2 Luck and +1 Speed, but you can just go with Spicy Eel
Late game:
Lucky Lunch + Coffee/Espresso for +3 Luck and +1 Speed
So my typical Skull Cavern loadout from L to R in my inventory is:
Sword, Pick, 200+ Stairs, 100 Bombs, [spaces], 3 Lucky Lunch, 3 Espresso, 40

Cheese
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Strategy is simple:
1. Skip levels down to 100 with Stairs but I sometimes stop past Level 60 if the floor is colorful with Gem nodes and I Bomb them
2. Skip ANY level with more than 1 Serpent. If you hate Serpents, skip
every one of these. Anything else you see on that floor is
irrelevant
3. Pause for a second and evaluate levels past 100. Is there a Gem or Ore Node concentration pretty close and not too many Monsters? No? Then
immediate Stairs Down. Yes? Then Bomb, grab, flail your Sword a bit if needed, and Stairs Down. Eat a Cheese,
never forget to eat too much cheese. Cheese is cheap, your time and SC run is not.
4. Enjoy the Treasure Rooms. This is really why I'm here, it's all about the treasure, muuaaaahhhahahahahhaahahaaaaa!
You're looking for chill floors with easy looting and the Treasure Rooms, so you'll be ignoring and bypassing 80-90% of all floors, even past 100. You're looking to make this
easy and getting into the floor-skipping mindset will make this happen.